The prevalence of acromegaly in hospitalized patients with type 2 diabetes.

نویسندگان

  • Kentaro Suda
  • Hidenori Fukuoka
  • Genzo Iguchi
  • Yushi Hirota
  • Hitoshi Nishizawa
  • Hironori Bando
  • Ryusaku Matsumoto
  • Michiko Takahashi
  • Kazuhiko Sakaguchi
  • Yutaka Takahashi
چکیده

The prevalence of acromegaly is estimated to be 8-24/100,000, but several recent studies suggest it is underestimated. In particular, acromegaly is considered more prevalent in patients with type 2 diabetes mellitus (T2DM) than in the normal population. This study aimed to evaluate the prevalence of acromegaly in hospitalized patients with T2DM. A total of 327 hospitalized patients with T2DM were recruited as subjects. If serum insulin-like growth factor 1 (IGF-1) levels were found to be elevated, random GH level was measured or oral glucose tolerance test (OGTT) was performed. Five patients with elevated serum IGF-1 levels and random GH level or inadequate suppression of GH in the OGTT underwent pituitary magnetic resonance imaging. Of those patients, pituitary adenoma was detected in 2 patients. These 2 patients were diagnosed with acromegaly, as they also exhibited mild acromegalic features. Intriguingly, both these patients exhibited severe macroangiopathy and an absence of microangiopathy. The prevalence of acromegaly in the hospitalized patients with T2DM in this study was therefore 0.6%, suggesting a higher prevalence than that predicted. Although a large-scale prospective study is required to clarify the precise prevalence of acromegaly in hospitalized patients with T2DM, the present study shows that it is useful to screen hospitalized patients with T2DM for acromegaly by measuring their serum IGF-1 level.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Prevalence of Type 1 Diabetes in Children of Mazandaran Province

Introduction: The prevalence of type 1 diabetes in all countries throughout the world is different. In this study, an introduction is, therefore, provided for the development of type 1 diabetes in children in Mazandaran province by using all available resources. Methods: In this descriptive cross-sectional study, the prevalence of patients with initial diagnosis of type 1 diabetes mellitus, ag...

متن کامل

بررسی شیوع دیابت در بیماران بستری مبتلا به اختلال دو قطبی

Abstract Objectives: The study was implemented to investigate the prevalence of Diabetes Mellitus in the hospitalized patients suffering from bipolar disorder in Shiraz. Method: The subjects were 384 bipolar patients (192 female and 192 male) hospitalized in the psychiatric wards of Ibne’Sina and Hafez hospitals in Shiraz. The subjects' age range was between 13 to 85 years their history of diab...

متن کامل

Aberrations in carbohydrate metabolism in patients with diagnosed acromegaly, hospitalized in the Endocrinology and Diabetology Department of Collegium Medicum

Introduction: The incidence rate of acromegaly is 50 to70 persons per one million people. It occurs twice as often in women than in men, especially in middle age. In the course of the disease, insulin resistance develops, which is connected with the hypersecretion of somatotropin. Type 2 diabetes mellitus occurs more frequently in patients with acromegaly than in the rest of the population. It ...

متن کامل

Hypertension and Type 2 Diabetes: A Cross-sectional Study in Hospitalized Patients in Quchan,Iran

Abstract Objective: Diabetes and hypertension are among the commonest diseases in developed countries, and the frequency of both diseases rises with age. By progression of diabetes the incidence of hypertension become higher than the age-matched general population. Materials and Methods: A cross-sectional study was carried out on 300 type 2 diabetic patients who were admitted to medical ward ...

متن کامل

Prevalence of androgenetic alopecia in patients and its relationship with the history of coronary heart disease

Background and Aim: Androgenetic alopecia is a type of androgen and genetic dependent hair loss and although it is more of a beauty issue, but in recent years studies have shown that this type of alopecia is associated with underlying disorders such as coronary artery disease. The aim of this study was to evaluate the frequency of androgenetic alopecia in hospitalized patients and its relations...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Endocrine journal

دوره 62 1  شماره 

صفحات  -

تاریخ انتشار 2015